Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α
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چکیده
منابع مشابه
Oxidative stress is enhanced by hypothermia imposed on cerulein-induced pancreatitis in rats.
BACKGROUND Hypothermia is a frequent event in severe acute pancreatitis (AP) and its real effects on the normal pancreas have not been well demonstrated. Moreover, neither have its effects on the outcome of acute pancreatitis been fully investigated. One hypothesis is that oxidative stress may be implicated in lesions caused or treated by hypothermia. AIM OF THE STUDY To investigate the effec...
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Oxidative stress is an important regulator in the pathogenesis of acute pancreatitis (AP). Reactive oxygen species induce activation of inflammatory cascades, inflammatory cell recruitment, and tissue damage. NF-κB regulates inflammatory cytokine gene expression, which induces an acute, edematous form of pancreatitis. Protein kinase C δ (PKCδ) activates NF-κB as shown in a mouse model of cerule...
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متن کاملThe role of nitric oxide in experimental cerulein induced pancreatitis.
An enhanced formation of nitric oxide (NO), due to the induction of inducible nitric oxide synthase (iNOS), has been implicated in the pathogenesis of shock and inflammation, but its role in acute pancreatitis still remains controversial. To clarify the role of NO in acute pancreatitis, the present experiment investigated the expression of iNOS and the effect of NOS inhibition on cerulein-induc...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2010
ISSN: 1007-9327
DOI: 10.3748/wjg.v16.i44.5565